Inhibition of Src Kinase Blocks High Glucose–Induced EGFR Transactivation and Collagen Synthesis in Mesangial Cells and Prevents Diabetic Nephropathy in Mice

Chronic exposure to high glucose leads to diabetic nephropathy characterized by increased mesangial matrix protein (e.g., collagen) accumulation. Altered cell signaling and gene expression accompanied by oxidative stress have been documented. The contribution of the tyrosine kinase, c-Src (Src), whi...

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Detalles Bibliográficos
Autores principales: Taniguchi, Kanta, Xia, Ling, Goldberg, Howard J., Lee, Ken W.K., Shah, Anu, Stavar, Laura, Masson, Elodie A.Y., Momen, Abdul, Shikatani, Eric A., John, Rohan, Husain, Mansoor, Fantus, I. George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806624/
https://www.ncbi.nlm.nih.gov/pubmed/23942551
http://dx.doi.org/10.2337/db12-1010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806624/
https://www.ncbi.nlm.nih.gov/pubmed/23942551
http://dx.doi.org/10.2337/db12-1010

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