Genome-Wide Transcriptional Effects of the Anti-Cancer Agent Camptothecin

The anti-cancer drug camptothecin inhibits replication and transcription by trapping DNA topoisomerase I (Top1) covalently to DNA in a “cleavable complex”. To examine the effects of camptothecin on RNA synthesis genome-wide we used Bru-Seq and show that camptothecin treatment primarily affected tran...

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Detalles Bibliográficos
Autores principales: Veloso, Artur, Biewen, Benjamin, Paulsen, Michelle T., Berg, Nathan, Carmo de Andrade Lima, Leonardo, Prasad, Jayendra, Bedi, Karan, Magnuson, Brian, Wilson, Thomas E., Ljungman, Mats
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806802/
https://www.ncbi.nlm.nih.gov/pubmed/24194914
http://dx.doi.org/10.1371/journal.pone.0078190

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806802/
https://www.ncbi.nlm.nih.gov/pubmed/24194914
http://dx.doi.org/10.1371/journal.pone.0078190

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