The Tumor Targeted Superantigen ABR-217620 Selectively Engages TRBV7-9 and Exploits TCR-pMHC Affinity Mimicry in Mediating T Cell Cytotoxicity

The T lymphocytes are the most important effector cells in immunotherapy of cancer. The conceptual objective for developing the tumor targeted superantigen (TTS) ABR-217620 (naptumomab estafenatox, 5T4Fab-SEA/E-120), now in phase 3 studies for advanced renal cell cancer, was to selectively coat tumo...

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Detalles Bibliográficos
Autores principales: Hedlund, Gunnar, Eriksson, Helena, Sundstedt, Anette, Forsberg, Göran, Jakobsen, Bent K., Pumphrey, Nicholas, Rödström, Karin, Lindkvist-Petersson, Karin, Björk, Per
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806850/
https://www.ncbi.nlm.nih.gov/pubmed/24194959
http://dx.doi.org/10.1371/journal.pone.0079082

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806850/
https://www.ncbi.nlm.nih.gov/pubmed/24194959
http://dx.doi.org/10.1371/journal.pone.0079082

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