The Engineered Thymidylate Kinase (TMPK)/AZT Enzyme-Prodrug Axis Offers Efficient Bystander Cell Killing for Suicide Gene Therapy of Cancer

We previously described a novel suicide (or ‘cell fate control’) gene therapy enzyme/prodrug system based on an engineered variant of human thymidylate kinase (TMPK) that potentiates azidothymidine (AZT) activation. Delivery of a suicide gene sequence into tumors by lentiviral transduction embodies...

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Detalles Bibliográficos
Autores principales: Sato, Takeya, Neschadim, Anton, Lavie, Arnon, Yanagisawa, Teruyuki, Medin, Jeffrey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806853/
https://www.ncbi.nlm.nih.gov/pubmed/24194950
http://dx.doi.org/10.1371/journal.pone.0078711

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806853/
https://www.ncbi.nlm.nih.gov/pubmed/24194950
http://dx.doi.org/10.1371/journal.pone.0078711

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