Cargando…

4-hydroxy-2(E)-Nonenal facilitates NMDA-Induced Neurotoxicity via Triggering Mitochondrial Permeability Transition Pore Opening and Mitochondrial Calcium Overload

N-methyl-D-aspartate (NMDA) receptor-mediated excitotoxicity is one of the major causes for neuronal cell death during cerebral ischemic insult. Previously, we reported that the final product of lipid membrane peroxidation 4-hydroxy-2E-nonenal (HNE) synergistically increased NMDA receptor-mediated e...

Descripción completa

Detalles Bibliográficos
Autores principales: Choi, In-Young, Lim, Ji-Hyae, Kim, Chunsook, Song, Hwa Young, Ju, Chung, Kim, Won-Ki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Brain and Neural Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807006/
https://www.ncbi.nlm.nih.gov/pubmed/24167414
http://dx.doi.org/10.5607/en.2013.22.3.200