Cargando…

Structure of an atypical periplasmic adaptor from a multidrug efflux pump of the spirochete Borrelia burgdorferi

Periplasmic adaptor proteins are essential components of bacterial tripartite multidrug efflux pumps. Here we report the 2.35 Å resolution crystal structure of the BesA adaptor from the spirochete Borrelia burgdorferi solved using selenomethionine derivatized protein. BesA shows the archetypal linea...

Descripción completa

Detalles Bibliográficos
Autores principales:	Greene, Nicholas P., Hinchliffe, Philip, Crow, Allister, Ababou, Abdessamad, Hughes, Colin, Koronakis, Vassilis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Science B.V 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807786/ https://www.ncbi.nlm.nih.gov/pubmed/23851070 http://dx.doi.org/10.1016/j.febslet.2013.06.056

Ejemplares similares

Structure of the periplasmic adaptor protein from a major facilitator superfamily (MFS) multidrug efflux pump
por: Hinchliffe, Philip, et al.
Publicado: (2014)

Structures of Gate Loop Variants of the AcrB Drug Efflux Pump Bound by Erythromycin Substrate
por: Ababou, Abdessamad, et al.
Publicado: (2016)

Recent discoveries and advancements in research on the Lyme disease spirochete Borrelia burgdorferi
por: Winslow, Christa, et al.
Publicado: (2019)

Architecture and roles of periplasmic adaptor proteins in tripartite eﬄux assemblies
por: Symmons, Martyn F., et al.
Publicado: (2015)

Genome Stability of Lyme Disease Spirochetes: Comparative Genomics of Borrelia burgdorferi Plasmids
por: Casjens, Sherwood R., et al.
Publicado: (2012)

Population Bottlenecks during the Infectious Cycle of the Lyme Disease Spirochete Borrelia burgdorferi
por: Rego, Ryan O. M., et al.
Publicado: (2014)

The cyclic-di-GMP signaling pathway in the Lyme disease spirochete, Borrelia burgdorferi
por: Novak, Elizabeth A., et al.
Publicado: (2014)

Detecting the Lyme Disease Spirochete, Borrelia Burgdorferi, in Ticks Using Nested PCR
por: Wills, Melanie K. B., et al.
Publicado: (2018)

DksA Controls the Response of the Lyme Disease Spirochete Borrelia burgdorferi to Starvation
por: Boyle, William K., et al.
Publicado: (2019)

White-Tailed Deer Serum Kills the Lyme Disease Spirochete, Borrelia burgdorferi
por: Pearson, Patrick, et al.
Publicado: (2023)

Molecular detection of Spirochetes and Borrelia burgdorferi in stray dogs of Nineveh province, Iraq
por: Ajaj, Eva Ayser, et al.
Publicado: (2023)

Correction: Population Bottlenecks during the Infectious Cycle of the Lyme Disease Spirochete Borrelia burgdorferi
Publicado: (2014)

Fluorescent Proteins, Promoters, and Selectable Markers for Applications in the Lyme Disease Spirochete Borrelia burgdorferi
por: Takacs, Constantin N., et al.
Publicado: (2018)

Borrelia burgdorferi, the Lyme disease spirochete, possesses genetically-encoded responses to doxycycline, but not to amoxicillin
por: Saylor, Timothy C., et al.
Publicado: (2022)

Vector competence studies with hard ticks and Borrelia burgdorferi sensu lato spirochetes: A review
por: Eisen, Lars
Publicado: (2019)

Development and validation of a FACS-based lipoprotein localization screen in the Lyme disease spirochete Borrelia burgdorferi
por: Kumru, Ozan S, et al.
Publicado: (2010)

A possible role for inflammation in mediating apoptosis of oligodendrocytes as induced by the Lyme disease spirochete Borrelia burgdorferi
por: Ramesh, Geeta, et al.
Publicado: (2012)

Early Cytokine Release in Response to Live Borrelia burgdorferi Sensu Lato Spirochetes Is Largely Complement Independent
por: Sandholm, Kerstin, et al.
Publicado: (2014)

The Lyme disease spirochete Borrelia burgdorferi induces inflammation and apoptosis in cells from dorsal root ganglia
por: Ramesh, Geeta, et al.
Publicado: (2013)

Prevalence of the Lyme Disease Spirochete, Borrelia burgdorferi, in Blacklegged Ticks, Ixodes scapularis at Hamilton-Wentworth, Ontario
por: Scott, John D., et al.
Publicado: (2016)

Cryo-electron tomography of periplasmic flagella in Borrelia burgdorferi reveals a distinct cytoplasmic ATPase complex
por: Qin, Zhuan, et al.
Publicado: (2018)

Interchangeability of periplasmic adaptor proteins AcrA and AcrE in forming functional efflux pumps with AcrD in Salmonella enterica serovar Typhimurium
por: Alav, Ilyas, et al.
Publicado: (2021)

The multifaceted responses of primary human astrocytes and brain microvascular endothelial cells to the Lyme disease spirochete, Borrelia burgdorferi
por: Brissette, Catherine A., et al.
Publicado: (2013)

The telomere resolvase of the Lyme disease spirochete, Borrelia burgdorferi, promotes DNA single-strand annealing and strand exchange
por: Mir, Taskia, et al.
Publicado: (2013)

The RpoS Gatekeeper in Borrelia burgdorferi: An Invariant Regulatory Scheme That Promotes Spirochete Persistence in Reservoir Hosts and Niche Diversity
por: Caimano, Melissa J., et al.
Publicado: (2019)

Identification and functional analysis of a galactosyltransferase capable of cholesterol glycolipid formation in the Lyme disease spirochete Borrelia burgdorferi
por: Hove, Petronella R., et al.
Publicado: (2021)

BB0259 Encompasses a Peptidoglycan Lytic Enzyme Function for Proper Assembly of Periplasmic Flagella in Borrelia burgdorferi
por: Xu, Hui, et al.
Publicado: (2021)

Divergence of Borrelia burgdorferi sensu lato spirochetes could be driven by the host: diversity of Borrelia strains isolated from ticks feeding on a single bird
por: Rudenko, Nataliia, et al.
Publicado: (2014)

Strict Conservation yet Non-Essential Nature of Plasmid Gene bba40 in the Lyme Disease Spirochete Borrelia burgdorferi
por: Kasumba, Irene N., et al.
Publicado: (2023)

An RND-Type Efflux System in Borrelia burgdorferi Is Involved in Virulence and Resistance to Antimicrobial Compounds
por: Bunikis, Ignas, et al.
Publicado: (2008)

Antibiotic Resistance Mediated by the MacB ABC Transporter Family: A Structural and Functional Perspective
por: Greene, Nicholas P., et al.
Publicado: (2018)

Corrigendum: Antibiotic Resistance Mediated by the MacB ABC Transporter Family: A Structural and Functional Perspective
por: Greene, Nicholas P., et al.
Publicado: (2018)

Treponema pallidum Lipoprotein TP0435 Expressed in Borrelia burgdorferi Produces Multiple Surface/Periplasmic Isoforms and mediates Adherence
por: Chan, Kamfai, et al.
Publicado: (2016)

Borrelia burgdorferi Sensu Lato Spirochetes in Wild Birds in Northwestern California: Associations with Ecological Factors, Bird Behavior and Tick Infestation
por: Newman, Erica A., et al.
Publicado: (2015)

Failure of the Asian longhorned tick, Haemaphysalis longicornis, to serve as an experimental vector of the Lyme disease spirochete, Borrelia burgdorferi sensu stricto
por: Breuner, Nicole E., et al.
Publicado: (2019)

Global ecology and epidemiology of Borrelia garinii spirochetes
por: Comstedt, Pär, et al.
Publicado: (2011)

Borrelia spirochetes in European exotic farm animals
por: Hrnková, Johana, et al.
Publicado: (2022)

Biochemistry of Bacterial Multidrug Efflux Pumps
por: Kumar, Sanath, et al.
Publicado: (2012)

Microbial Primer: Multidrug efflux pumps
por: Siasat, Pauline Ann, et al.
Publicado: (2023)

A role for the periplasmic adaptor protein AcrA in vetting substrate access to the RND efflux transporter AcrB
por: Alav, Ilyas, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_6deln7b4mq2cneb9rda6lj0ebe