Spontaneous Variants of the [RNQ+] Prion in Yeast Demonstrate the Extensive Conformational Diversity Possible with Prion Proteins

Prion strains (or variants) are structurally distinct amyloid conformations arising from a single polypeptide sequence. The existence of prion strains has been well documented in mammalian prion diseases. In many cases, prion strains manifest as variation in disease progression and pathology, and in...

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Detalles Bibliográficos
Autores principales: Huang, Vincent J., Stein, Kevin C., True, Heather L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808357/
https://www.ncbi.nlm.nih.gov/pubmed/24205387
http://dx.doi.org/10.1371/journal.pone.0079582

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808357/
https://www.ncbi.nlm.nih.gov/pubmed/24205387
http://dx.doi.org/10.1371/journal.pone.0079582

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