Human α1-Antitrypsin Binds to Heat-Shock Protein gp96 and Protects from Endogenous gp96-Mediated Injury In vivo

The extracellular form of the abundant heat-shock protein, gp96, is involved in human autoimmune pathologies. In patients with type 1 diabetes, circulating gp96 is found to be elevated, and is bound to the acute-phase protein, α1-antitrypsin (AAT). The two molecules also engage intracellularly durin...

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Detalles Bibliográficos
Autores principales: Ochayon, David E., Mizrahi, Mark, Shahaf, Galit, Baranovski, Boris M., Lewis, Eli C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808895/
https://www.ncbi.nlm.nih.gov/pubmed/24191154
http://dx.doi.org/10.3389/fimmu.2013.00320

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808895/
https://www.ncbi.nlm.nih.gov/pubmed/24191154
http://dx.doi.org/10.3389/fimmu.2013.00320

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