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Discriminant analysis of prion sequences for prediction of susceptibility

Prion diseases, including ovine scrapie, bovine spongiform encephalopathy (BSE), human kuru and Creutzfeldt–Jakob disease (CJD), originate from a conformational change of the normal cellular prion protein (PrP(C)) into abnormal protease-resistant prion protein (PrP(Sc)). There is concern regarding t...

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Detalles Bibliográficos
Autores principales: Lee, Ji-Hae, Bae, Se-Eun, Jung, Sunghoon, Ahn, Insung, Son, Hyeon Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809358/
https://www.ncbi.nlm.nih.gov/pubmed/24113272
http://dx.doi.org/10.1038/emm.2013.100