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Cancer cell metabolism: implications for therapeutic targets
Cancer cell metabolism is characterized by an enhanced uptake and utilization of glucose, a phenomenon known as the Warburg effect. The persistent activation of aerobic glycolysis in cancer cells can be linked to activation of oncogenes or loss of tumor suppressors, thereby fundamentally advancing c...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809361/ https://www.ncbi.nlm.nih.gov/pubmed/24091747 http://dx.doi.org/10.1038/emm.2013.85 |
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author | Jang, Miran Kim, Sung Soo Lee, Jinhwa |
author_facet | Jang, Miran Kim, Sung Soo Lee, Jinhwa |
author_sort | Jang, Miran |
collection | PubMed |
description | Cancer cell metabolism is characterized by an enhanced uptake and utilization of glucose, a phenomenon known as the Warburg effect. The persistent activation of aerobic glycolysis in cancer cells can be linked to activation of oncogenes or loss of tumor suppressors, thereby fundamentally advancing cancer progression. In this respect, inhibition of glycolytic capacity may contribute to an anticancer effect on malignant cells. Understanding the mechanisms of aerobic glycolysis may present a new basis for cancer treatment. Accordingly, interrupting lactate fermentation and/or other cancer-promoting metabolic sites may provide a promising strategy to halt tumor development. In this review, we will discuss dysregulated and reprogrammed cancer metabolism followed by clinical relevance of the metabolic enzymes, such as hexokinase, phosphofructokinase, pyruvate kinase M2, lactate dehydrogenase, pyruvate dehydrogenase kinase and glutaminase. The proper intervention of these metabolic sites may provide a therapeutic advantage that can help overcome resistance to chemotherapy or radiotherapy. |
format | Online Article Text |
id | pubmed-3809361 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-38093612013-10-28 Cancer cell metabolism: implications for therapeutic targets Jang, Miran Kim, Sung Soo Lee, Jinhwa Exp Mol Med Review Cancer cell metabolism is characterized by an enhanced uptake and utilization of glucose, a phenomenon known as the Warburg effect. The persistent activation of aerobic glycolysis in cancer cells can be linked to activation of oncogenes or loss of tumor suppressors, thereby fundamentally advancing cancer progression. In this respect, inhibition of glycolytic capacity may contribute to an anticancer effect on malignant cells. Understanding the mechanisms of aerobic glycolysis may present a new basis for cancer treatment. Accordingly, interrupting lactate fermentation and/or other cancer-promoting metabolic sites may provide a promising strategy to halt tumor development. In this review, we will discuss dysregulated and reprogrammed cancer metabolism followed by clinical relevance of the metabolic enzymes, such as hexokinase, phosphofructokinase, pyruvate kinase M2, lactate dehydrogenase, pyruvate dehydrogenase kinase and glutaminase. The proper intervention of these metabolic sites may provide a therapeutic advantage that can help overcome resistance to chemotherapy or radiotherapy. Nature Publishing Group 2013-10 2013-10-04 /pmc/articles/PMC3809361/ /pubmed/24091747 http://dx.doi.org/10.1038/emm.2013.85 Text en Copyright © 2013 KSBMB. http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ |
spellingShingle | Review Jang, Miran Kim, Sung Soo Lee, Jinhwa Cancer cell metabolism: implications for therapeutic targets |
title | Cancer cell metabolism: implications for therapeutic targets |
title_full | Cancer cell metabolism: implications for therapeutic targets |
title_fullStr | Cancer cell metabolism: implications for therapeutic targets |
title_full_unstemmed | Cancer cell metabolism: implications for therapeutic targets |
title_short | Cancer cell metabolism: implications for therapeutic targets |
title_sort | cancer cell metabolism: implications for therapeutic targets |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809361/ https://www.ncbi.nlm.nih.gov/pubmed/24091747 http://dx.doi.org/10.1038/emm.2013.85 |
work_keys_str_mv | AT jangmiran cancercellmetabolismimplicationsfortherapeutictargets AT kimsungsoo cancercellmetabolismimplicationsfortherapeutictargets AT leejinhwa cancercellmetabolismimplicationsfortherapeutictargets |