Aspirin-induced Bcl-2 translocation and its phosphorylation in the nucleus trigger apoptosis in breast cancer cells

Here, we report that B-cell lymphoma 2 (Bcl-2) is a novel target molecule of aspirin in breast cancer cells. Aspirin influenced the formation of a complex by Bcl-2 and FKBP38 and induced the nuclear translocation of Bcl-2 and its phosphorylation. These events inhibited cancer cell proliferation and...

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Detalles Bibliográficos
Autores principales: Choi, Bo-Hwa, Chakraborty, Goutam, Baek, Kwanghee, Yoon, Ho Sup
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809363/
https://www.ncbi.nlm.nih.gov/pubmed/24113271
http://dx.doi.org/10.1038/emm.2013.91

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809363/
https://www.ncbi.nlm.nih.gov/pubmed/24113271
http://dx.doi.org/10.1038/emm.2013.91

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