Loss of VHL in RCC Reduces Repair and Alters Cellular Response to Benzo[a]pyrene

Mutations of the von Hippel-Lindau (VHL) tumor suppressor gene occur in the majority of sporadic renal-cell carcinomas (RCC). Loss of VHL function is associated with stabilization of hypoxia-inducible factor α (HIFα). We and others demonstrated that there is a two-way interaction between the aryl hy...

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Detalles Bibliográficos
Autores principales: Schults, Marten A., Oligschlaeger, Yvonne, Godschalk, Roger W., Van Schooten, Frederik-Jan, Chiu, Roland K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809518/
https://www.ncbi.nlm.nih.gov/pubmed/24195061
http://dx.doi.org/10.3389/fonc.2013.00270

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809518/
https://www.ncbi.nlm.nih.gov/pubmed/24195061
http://dx.doi.org/10.3389/fonc.2013.00270

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