A Critical Role for the Putative NCS2 Nucleobase Permease YjcD in the Sensitivity of Escherichia coli to Cytotoxic and Mutagenic Purine Analogs

The base analogs 6-N-hydroxylaminopurine (HAP) and 2-amino-HAP (AHAP) are potent mutagens in bacteria and eukaryotic organisms. Previously, we demonstrated that a defect in the Escherichia coli ycbX gene, encoding a molybdenum cofactor-dependent oxidoreductase, dramatically enhances sensitivity to t...

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Detalles Bibliográficos
Autores principales: Kozmin, Stanislav G., Stepchenkova, Elena I., Chow, Stephen C., Schaaper, Roel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809563/
https://www.ncbi.nlm.nih.gov/pubmed/24169576
http://dx.doi.org/10.1128/mBio.00661-13

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809563/
https://www.ncbi.nlm.nih.gov/pubmed/24169576
http://dx.doi.org/10.1128/mBio.00661-13

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