Successful Azathioprine Treatment with Metabolite Monitoring in a Pediatric Inflammatory Bowel Disease Patient Homozygous for TPMT(*)3C

Thiopurine S-methyltransferase (TPMT) methylates purine analogues, showing TPMT activity in inverse relation to concentrations of active metabolites such as 6-thioguanine nucleotide (6-TGN). With conventional dosing of thiopurines, patients with homozygous variant TPMT alleles consistently suffer fr...

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Detalles Bibliográficos
Autores principales: Lee, Mi-Na, Woo, Hye In, Lee, Yoo Min, Kang, Ben, Kim, Jong-Won, Choe, Yon Ho, Lee, Soo-Youn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809851/
https://www.ncbi.nlm.nih.gov/pubmed/24142665
http://dx.doi.org/10.3349/ymj.2013.54.6.1545

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809851/
https://www.ncbi.nlm.nih.gov/pubmed/24142665
http://dx.doi.org/10.3349/ymj.2013.54.6.1545

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