Cargando…

Variation in Cell Signaling Protein Expression May Introduce Sampling Bias in Primary Epithelial Ovarian Cancer

Although the expression of cell signaling proteins is used as prognostic and predictive biomarker, variability of protein levels within tumors is not well studied. We assessed intratumoral heterogeneity of protein expression within primary ovarian cancer. Full-length proteins were extracted from 88...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mittermeyer, Gabriele, Malinowsky, Katharina, Beese, Christian, Höfler, Heinz, Schmalfeldt, Barbara, Becker, Karl-Friedrich, Avril, Stefanie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810127/ https://www.ncbi.nlm.nih.gov/pubmed/24204986 http://dx.doi.org/10.1371/journal.pone.0077825

Ejemplares similares

Common Protein Biomarkers Assessed by Reverse Phase Protein Arrays Show Considerable Intratumoral Heterogeneity in Breast Cancer Tissues
por: Malinowsky, Katharina, et al.
Publicado: (2012)

Increased PDGFR-beta and VEGFR-2 protein levels are associated with resistance to platinum-based chemotherapy and adverse outcome of ovarian cancer patients
por: Avril, Stefanie, et al.
Publicado: (2017)

The E-cadherin repressor Snail is associated with lower overall survival of ovarian cancer patients
por: Blechschmidt, K, et al.
Publicado: (2008)

Evidence of Prognostic Relevant Expression Profiles of Heat-Shock Proteins and Glucose-Regulated Proteins in Oesophageal Adenocarcinomas
por: Slotta-Huspenina, Julia, et al.
Publicado: (2012)

Impact of Introducing a PACU24 Concept on the Perioperative Outcome of Patients with Advanced Ovarian Cancer Treated with Cytoreductive Surgery
por: Reuter, Susanne, et al.
Publicado: (2023)

Re-interpreting conventional interval estimates taking into account bias and extra-variation
por: Höfler, Michael, et al.
Publicado: (2006)

Discovery of New Molecular Subtypes in Oesophageal Adenocarcinoma
por: Berg, Daniela, et al.
Publicado: (2011)

CXCL9 and CXCL10 predict survival and are regulated by cyclooxygenase inhibition in advanced serous ovarian cancer
por: Bronger, Holger, et al.
Publicado: (2016)

Ovarian borderline tumors in the 2014 WHO classification: evolving concepts and diagnostic criteria
por: Hauptmann, Steffen, et al.
Publicado: (2016)

CXCR3 mediates ascites-directed tumor cell migration and predicts poor outcome in ovarian cancer patients
por: Windmüller, C, et al.
Publicado: (2017)

Activation of epidermal growth factor receptor results in Snail protein but not mRNA overexpression in endometrial cancer
por: Hipp, Susanne, et al.
Publicado: (2009)

PARP-1 may be involved in angiogenesis in epithelial ovarian cancer
por: Wei, Wei, et al.
Publicado: (2016)

Inflated Co-authorship Introduces Bias to Current Scientometric Indices
por: Masic, Izet, et al.
Publicado: (2021)

A specific expression profile of heat-shock proteins and glucose-regulated proteins is associated with response to neoadjuvant chemotherapy in oesophageal adenocarcinomas
por: Slotta-Huspenina, J, et al.
Publicado: (2013)

The PI3K/Akt/mTOR Pathway Is Implicated in the Premature Senescence of Primary Human Endothelial Cells Exposed to Chronic Radiation
por: Yentrapalli, Ramesh, et al.
Publicado: (2013)

Prognostic significance of urokinase (uPA) and its inhibitor PAI-1 for survival in advanced ovarian carcinoma stage FIGO IIIc
por: Kuhn, W, et al.
Publicado: (1999)

Activation of the PI3K/AKT pathway correlates with prognosis in stage II colon cancer
por: Malinowsky, K, et al.
Publicado: (2014)

Use of trihalomethanes as a surrogate for haloacetonitrile exposure introduces misclassification bias
por: Furst, Kirin E., et al.
Publicado: (2021)

Altered glutamine metabolism in platinum resistant ovarian cancer
por: Hudson, Chantelle D., et al.
Publicado: (2016)

The PAXgene(®) Tissue System Preserves Phosphoproteins in Human Tissue Specimens and Enables Comprehensive Protein Biomarker Research
por: Gündisch, Sibylle, et al.
Publicado: (2013)

Ovarian Cancer-Cell Pericellular Hyaluronan Deposition Negatively Impacts Prognosis of Ovarian Cancer Patients
por: Oliveira-Ferrer, Leticia, et al.
Publicado: (2022)

Global decline in semen quality: ignoring the developing world introduces selection bias
por: Deonandan, Raywat, et al.
Publicado: (2012)

A quantitative screening method to detect rater-introduced bias in clinical ratings
por: Krogh, Mogens A, et al.
Publicado: (2012)

Male-biased migration from East Africa introduced pastoralism into southern Africa
por: Vicente, Mário, et al.
Publicado: (2021)

Library Preparation and Sequencing Platform Introduce Bias in Metagenomic-Based Characterizations of Microbiomes
por: Poulsen, Casper S., et al.
Publicado: (2022)

Poly(a) selection introduces bias and undue noise in direct RNA-sequencing
por: Viscardi, Marcus J., et al.
Publicado: (2022)

Chemosensory Communication of Gender Information: Masculinity Bias in Body Odor Perception and Femininity Bias Introduced by Chemosignals During Social Perception
por: Mutic, Smiljana, et al.
Publicado: (2016)

Targeted therapies in cancer - challenges and chances offered by newly developed techniques for protein analysis in clinical tissues
por: Malinowsky, K, et al.
Publicado: (2010)

The T7-Primer Is a Source of Experimental Bias and Introduces Variability between Microarray Platforms
por: Kerkhoven, Ron M., et al.
Publicado: (2008)

Stereochemical bias introduced during RNA synthesis modulates the activity of phosphorothioate siRNAs
por: Jahns, Hartmut, et al.
Publicado: (2015)

Reducing inherent biases introduced during DNA viral metagenome analyses of municipal wastewater
por: Brinkman, Nichole E., et al.
Publicado: (2018)

Cell Dispersal Influences Tumor Heterogeneity and Introduces a Bias in NGS Data Interpretation
por: Pongor, Lőrinc, et al.
Publicado: (2017)

Chromatin structure can introduce systematic biases in genome-wide analyses of Plasmodium falciparum
por: Baumgarten, Sebastian, et al.
Publicado: (2022)

Advanced In Vivo Prediction by Introducing Biphasic Dissolution Data into PBPK Models
por: Denninger, Alexander, et al.
Publicado: (2023)

Asbestos Exposure and Ovarian Cancer – a Gynaecological Occupational Disease. Background, Mandatory Notification, Practical Approach
por: Nowak, Dennis, et al.
Publicado: (2021)

Critical roles of specimen type and temperature before and during fixation in the detection of phosphoproteins in breast cancer tissues
por: Gündisch, Sibylle, et al.
Publicado: (2015)

VEGF-C expression attributes the risk for lymphatic metastases to ovarian cancer patients
por: Kuerti, Sascha, et al.
Publicado: (2017)

Randomised controlled trial testing the feasibility of an exercise and nutrition intervention for patients with ovarian cancer during and after first-line chemotherapy (BENITA-study)
por: Maurer, Tabea, et al.
Publicado: (2022)

Peritoneal tumor spread in serous ovarian cancer-epithelial mesenchymal status and outcome
por: Auer, Katharina, et al.
Publicado: (2015)

The positivity of estrogen receptor and progesterone receptor may not be associated with metastasis and recurrence in epithelial ovarian cancer
por: Chen, Shouzhen, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_dh160abq5br90eallsrq1ktaio