Preferential Selectivity of Inhibitors with Human Tau Protein Kinase Gsk3β Elucidates Their Potential Roles for Off-Target Alzheimer's Therapy

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the accumulation of amyloid beta peptides (Aβ) and neurofibrillary tangles (NFTs). The abnormal phosphorylation of tau leads to the formation of NFTs produced by the action of tau kinases, resulting in the loss of neurons...

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Detalles Bibliográficos
Autores principales: Kumar Dasappa, Jagadeesh, Nagendra, H. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810200/
https://www.ncbi.nlm.nih.gov/pubmed/24222885
http://dx.doi.org/10.1155/2013/809386

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810200/
https://www.ncbi.nlm.nih.gov/pubmed/24222885
http://dx.doi.org/10.1155/2013/809386

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