A novel chemopreventive mechanism of selenomethionine: Enhancement of APE1 enzyme activity via a Gadd45a, PCNA and APE1 protein complex that regulates p53-mediated base excision repair

Organic selenium compounds have been documented to play a role in cancer prevention. Our previous study showed that selenomethionine (SeMet) induces p53 activation without genotoxic effects including apoptosis and cell cycle arrest. In this study, we investigated the mechanism by which organic selen...

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Detalles Bibliográficos
Autores principales: JUNG, HWA JIN, KIM, HYE LIM, KIM, YEO JIN, WEON, JONG-IL, SEO, YOUNG ROK
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810451/
https://www.ncbi.nlm.nih.gov/pubmed/23846616
http://dx.doi.org/10.3892/or.2013.2613

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810451/
https://www.ncbi.nlm.nih.gov/pubmed/23846616
http://dx.doi.org/10.3892/or.2013.2613

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