Inhibition of the hypoxia-inducible factor pathway by a G-quadruplex binding small molecule

The hypoxia-inducible transcription factor (HIF) co-ordinates the response of tumours to low oxygen by stimulating genes involved in metabolism and angiogenesis. HIF pathway activation is associated with decreased progression-free survival and increased mortality; compounds that target this pathway...

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Detalles Bibliográficos
Autores principales: Welsh, Sarah J., Dale, Aaron G., Lombardo, Caterina M., Valentine, Helen, de la Fuente, Maria, Schatzlein, Andreas, Neidle, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810677/
https://www.ncbi.nlm.nih.gov/pubmed/24165797
http://dx.doi.org/10.1038/srep02799

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810677/
https://www.ncbi.nlm.nih.gov/pubmed/24165797
http://dx.doi.org/10.1038/srep02799

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