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Evaluation of the Expression of C-kit (CD117) in Ependymomas and Oligodendrogliomas

C-kit is a proto-oncogene located on the long arm of chromosome 4. Its product, CD117, is a specific immunohistochemical (IHQ) marker that is associated with response to a potent tyrosine kinase inhibitor therapy with STI-571 (Gleevec®) in chronic myelogenous leukemia and GISTs. In our study, we aim...

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Autores principales: Zavalhia, Lisiane Silveira, Romitti, Mirian, Netto, Gabriel Corteze, dos Santos, Giovana Tavares, Meurer, Rosalva Thereza, Hilbig, Arlete, Michalowski, Mariana Bohns, Ribeiro, Marlise de Castro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810688/
https://www.ncbi.nlm.nih.gov/pubmed/22846208
http://dx.doi.org/10.3233/DMA-2012-0905
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author Zavalhia, Lisiane Silveira
Romitti, Mirian
Netto, Gabriel Corteze
dos Santos, Giovana Tavares
Meurer, Rosalva Thereza
Hilbig, Arlete
Michalowski, Mariana Bohns
Ribeiro, Marlise de Castro
author_facet Zavalhia, Lisiane Silveira
Romitti, Mirian
Netto, Gabriel Corteze
dos Santos, Giovana Tavares
Meurer, Rosalva Thereza
Hilbig, Arlete
Michalowski, Mariana Bohns
Ribeiro, Marlise de Castro
author_sort Zavalhia, Lisiane Silveira
collection PubMed
description C-kit is a proto-oncogene located on the long arm of chromosome 4. Its product, CD117, is a specific immunohistochemical (IHQ) marker that is associated with response to a potent tyrosine kinase inhibitor therapy with STI-571 (Gleevec®) in chronic myelogenous leukemia and GISTs. In our study, we aimed to evaluate the expression of CD117 in glial tumors as this finding may guide therapeutic approaches for these brain tumors. Ependymomas and oligodendrogliomas, in formalin fixed and paraffin embedded blocks were assayed for CD117 immunoreactivity using anti-c-kit (CD117, DAKO). GISTs were used as positive control. We observed immunoreactivity of CD117 protein in 25.5% of tumors in both histological types. In oligodendrogliomas, there was an association between older age at diagnosis and positivity for CD117 (P = 0.039). In addition, we observed an association between higher tumor grade (grade III) and positivity for CD117 (P = 0.007). No clinical association was observed in ependymomas (P > 0.05). This study encourages further investigations, considering that CD117 may be a possible oncogenic factor in some glial tumors. In this case, tumors that express this marker may eventually benefit from a therapy with selective inhibitors of receptor kinases.
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spelling pubmed-38106882013-12-10 Evaluation of the Expression of C-kit (CD117) in Ependymomas and Oligodendrogliomas Zavalhia, Lisiane Silveira Romitti, Mirian Netto, Gabriel Corteze dos Santos, Giovana Tavares Meurer, Rosalva Thereza Hilbig, Arlete Michalowski, Mariana Bohns Ribeiro, Marlise de Castro Dis Markers Other C-kit is a proto-oncogene located on the long arm of chromosome 4. Its product, CD117, is a specific immunohistochemical (IHQ) marker that is associated with response to a potent tyrosine kinase inhibitor therapy with STI-571 (Gleevec®) in chronic myelogenous leukemia and GISTs. In our study, we aimed to evaluate the expression of CD117 in glial tumors as this finding may guide therapeutic approaches for these brain tumors. Ependymomas and oligodendrogliomas, in formalin fixed and paraffin embedded blocks were assayed for CD117 immunoreactivity using anti-c-kit (CD117, DAKO). GISTs were used as positive control. We observed immunoreactivity of CD117 protein in 25.5% of tumors in both histological types. In oligodendrogliomas, there was an association between older age at diagnosis and positivity for CD117 (P = 0.039). In addition, we observed an association between higher tumor grade (grade III) and positivity for CD117 (P = 0.007). No clinical association was observed in ependymomas (P > 0.05). This study encourages further investigations, considering that CD117 may be a possible oncogenic factor in some glial tumors. In this case, tumors that express this marker may eventually benefit from a therapy with selective inhibitors of receptor kinases. IOS Press 2012 2012-07-19 /pmc/articles/PMC3810688/ /pubmed/22846208 http://dx.doi.org/10.3233/DMA-2012-0905 Text en Copyright © 2012 Hindawi Publishing Corporation.
spellingShingle Other
Zavalhia, Lisiane Silveira
Romitti, Mirian
Netto, Gabriel Corteze
dos Santos, Giovana Tavares
Meurer, Rosalva Thereza
Hilbig, Arlete
Michalowski, Mariana Bohns
Ribeiro, Marlise de Castro
Evaluation of the Expression of C-kit (CD117) in Ependymomas and Oligodendrogliomas
title Evaluation of the Expression of C-kit (CD117) in Ependymomas and Oligodendrogliomas
title_full Evaluation of the Expression of C-kit (CD117) in Ependymomas and Oligodendrogliomas
title_fullStr Evaluation of the Expression of C-kit (CD117) in Ependymomas and Oligodendrogliomas
title_full_unstemmed Evaluation of the Expression of C-kit (CD117) in Ependymomas and Oligodendrogliomas
title_short Evaluation of the Expression of C-kit (CD117) in Ependymomas and Oligodendrogliomas
title_sort evaluation of the expression of c-kit (cd117) in ependymomas and oligodendrogliomas
topic Other
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810688/
https://www.ncbi.nlm.nih.gov/pubmed/22846208
http://dx.doi.org/10.3233/DMA-2012-0905
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