Crystal structure of the S187F variant of human liver alanine: Aminotransferase associated with primary hyperoxaluria type I and its functional implications

The substitution of Ser187, a residue located far from the active site of human liver peroxisomal alanine:glyoxylate aminotransferase (AGT), by Phe gives rise to a variant associated with primary hyperoxaluria type I. Unexpectedly, previous studies revealed that the recombinant form of S187F exhibit...

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Detalles Bibliográficos
Autores principales: Oppici, Elisa, Fodor, Krisztian, Paiardini, Alessandro, Williams, Chris, Voltattorni, Carla Borri, Wilmanns, Matthias, Cellini, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810726/
https://www.ncbi.nlm.nih.gov/pubmed/23589421
http://dx.doi.org/10.1002/prot.24300

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810726/
https://www.ncbi.nlm.nih.gov/pubmed/23589421
http://dx.doi.org/10.1002/prot.24300

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