Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice

We examine the impact of targeted disruption of growth hormone-releasing hormone (GHRH) in mice on longevity and the putative mechanisms of delayed aging. GHRH knockout mice are remarkably long-lived, exhibiting major shifts in the expression of genes related to xenobiotic detoxification, stress res...

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Detalles Bibliográficos
Autores principales: Sun, Liou Y, Spong, Adam, Swindell, William R, Fang, Yimin, Hill, Cristal, Huber, Joshua A, Boehm, Jacob D, Westbrook, Reyhan, Salvatori, Roberto, Bartke, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2013
Materias:
Genes and Chromosomes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810783/
https://www.ncbi.nlm.nih.gov/pubmed/24175087
http://dx.doi.org/10.7554/eLife.01098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810783/
https://www.ncbi.nlm.nih.gov/pubmed/24175087
http://dx.doi.org/10.7554/eLife.01098

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