Postconditioning ameliorates mitochondrial DNA damage and deletion after renal ischemic injury

BACKGROUND: Reactive oxygen species (ROS) play a major role in causing injury in ischemia-reperfusion (I/R). Mitochondrial DNA (mtDNA) is particularly vulnerable to oxidative damage. We propose that increased mitochondrial ROS production is likely to damage mtDNA, causing further injury to mitochond...

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Detalles Bibliográficos
Autores principales: Tan, Xiaohua, Zhang, Lei, Jiang, Yunpeng, Yang, Yujia, Zhang, Wenqi, Li, Yulin, Zhang, Xiuying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811057/
https://www.ncbi.nlm.nih.gov/pubmed/24021677
http://dx.doi.org/10.1093/ndt/gft278

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