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Essential Role of the m(2)R-RGS6-I(KACh) Pathway in Controlling Intrinsic Heart Rate Variability

Normal heart function requires generation of a regular rhythm by sinoatrial pacemaker cells and the alteration of this spontaneous heart rate by the autonomic input to match physiological demand. However, the molecular mechanisms that ensure consistent periodicity of cardiac contractions and fine tu...

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Detalles Bibliográficos
Autores principales: Posokhova, Ekaterina, Ng, David, Opel, Aaisha, Masuho, Ikuo, Tinker, Andrew, Biesecker, Leslie G., Wickman, Kevin, Martemyanov, Kirill A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812209/
https://www.ncbi.nlm.nih.gov/pubmed/24204714
http://dx.doi.org/10.1371/journal.pone.0076973