Cargando…

Essential Role of the m(2)R-RGS6-I(KACh) Pathway in Controlling Intrinsic Heart Rate Variability

Normal heart function requires generation of a regular rhythm by sinoatrial pacemaker cells and the alteration of this spontaneous heart rate by the autonomic input to match physiological demand. However, the molecular mechanisms that ensure consistent periodicity of cardiac contractions and fine tu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Posokhova, Ekaterina, Ng, David, Opel, Aaisha, Masuho, Ikuo, Tinker, Andrew, Biesecker, Leslie G., Wickman, Kevin, Martemyanov, Kirill A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812209/ https://www.ncbi.nlm.nih.gov/pubmed/24204714 http://dx.doi.org/10.1371/journal.pone.0076973

Ejemplares similares

GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes
por: Orlandi, Cesare, et al.
Publicado: (2012)

RGS7/Gβ5/R7BP complex regulates synaptic plasticity and memory by modulating hippocampal GABA(B)R-GIRK signaling
por: Ostrovskaya, Olga, et al.
Publicado: (2014)

A Global Map of G Protein Signaling Regulation by RGS Proteins
por: Masuho, Ikuo, et al.
Publicado: (2020)

The Role of Inhibitory G Proteins and Regulators of G Protein Signaling in the in vivo Control of Heart Rate and Predisposition to Cardiac Arrhythmias
por: Ang, Richard, et al.
Publicado: (2012)

Gβ5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling
por: Xie, Keqiang, et al.
Publicado: (2010)

The influences of the M(2)R-GIRK4-RGS6 dependent parasympathetic pathway on electrophysiological properties of the mouse heart
por: Kulkarni, Kanchan, et al.
Publicado: (2018)

Correction: The influences of the M(2)R-GIRK4-RGS6 dependent parasympathetic pathway on electrophysiological properties of the mouse heart
por: Kulkarni, Kanchan, et al.
Publicado: (2018)

KaChing: how to run an online business that pays and pays
por: Comm, Joel
Publicado: (2010)

The G-protein–gated K(+) channel, I(KACh), is required for regulation of pacemaker activity and recovery of resting heart rate after sympathetic stimulation
por: Mesirca, Pietro, et al.
Publicado: (2013)

RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells
por: Qutob, Nouar, et al.
Publicado: (2018)

Author Correction: RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells
por: Qutob, Nouar, et al.
Publicado: (2019)

I(KACh) is constitutively active via PKC epsilon in aging mediated atrial fibrillation
por: Chang, Mengmeng, et al.
Publicado: (2022)

Striatal RGS7 Regulates Depression-Related Behaviors and Stress-Induced Reinstatement of Cocaine Conditioned Place Preference
por: Sutton, Laurie P., et al.
Publicado: (2021)

Cellular and Subcellular Localization of the RGS7/Gβ5/R7BP Complex in the Cerebellar Cortex
por: Aguado, Carolina, et al.
Publicado: (2016)

Pharmacogenomics of GPCR Drug Targets
por: Hauser, Alexander S., et al.
Publicado: (2018)

GNB5 mutation causes a novel neuropsychiatric disorder featuring attention deficit hyperactivity disorder, severely impaired language development and normal cognition
por: Shamseldin, Hanan E., et al.
Publicado: (2016)

The intriguing effect of ethanol and nicotine on acetylcholine-sensitive potassium current I(KAch): Insight from a quantitative model
por: Šimurda, Jiří, et al.
Publicado: (2019)

Influence of Continuous Training on Atrial Myocytes I(K1) and I(KAch) and on Induction of Atrial Fibrillation in a Rabbit Model
por: Yuan, Dou, et al.
Publicado: (2018)

Structural organization of a major neuronal G protein regulator, the RGS7-Gβ5-R7BP complex
por: Patil, Dipak N, et al.
Publicado: (2018)

Extended Phenotyping and Functional Validation Facilitate Diagnosis of a Complex Patient Harboring Genetic Variants in MCCC1 and GNB5 Causing Overlapping Phenotypes
por: Shao, Zhuo, et al.
Publicado: (2021)

Effects of Small Molecule Ligands on ACKR3 Receptors
por: Hopkins, Brittany E., et al.
Publicado: (2022)

The RGS gene loco is essential for male reproductive system differentiation in Drosophila melanogaster
por: McGurk, Leeanne, et al.
Publicado: (2008)

Attenuation of Acetylcholine Activated Potassium Current (I(KACh)) by Simvastatin, Not Pravastatin in Mouse Atrial Cardiomyocyte: Possible Atrial Fibrillation Preventing Effects of Statin
por: Cho, Kyoung-Im, et al.
Publicado: (2014)

A Regional Reduction in I(to) and I(KACh) in the Murine Posterior Left Atrial Myocardium Is Associated with Action Potential Prolongation and Increased Ectopic Activity
por: Holmes, Andrew P., et al.
Publicado: (2016)

LGR5 receptor promotes cell–cell adhesion in stem cells and colon cancer cells via the IQGAP1–Rac1 pathway
por: Carmon, Kendra S., et al.
Publicado: (2017)

Molecular Deconvolution Platform to Establish Disease Mechanisms by Surveying GPCR Signaling
por: Masuho, Ikuo, et al.
Publicado: (2018)

Eight RGS and RGS-like Proteins Orchestrate Growth, Differentiation, and Pathogenicity of Magnaporthe oryzae
por: Zhang, Haifeng, et al.
Publicado: (2011)

Characteristics of a Regulator of G-Protein Signaling (RGS) rgsC in Aspergillus fumigatus
por: Kim, Young, et al.
Publicado: (2017)

Cardiac RGS Proteins in Human Heart Failure and Atrial Fibrillation: Focus on RGS4
por: Borges, Jordana I., et al.
Publicado: (2023)

Translational control by RGS2
por: Nguyen, Chau H., et al.
Publicado: (2009)

Correction: Eight RGS and RGS-like Proteins Orchestrate Growth, Differentiation, and Pathogenicity of Magnaporthe oryzae
por: Zhang, Haifeng, et al.
Publicado: (2019)

Regulators of G-Protein signaling RGS10 and RGS17 regulate chemoresistance in ovarian cancer cells
por: Hooks, Shelley B, et al.
Publicado: (2010)

A RGS7-CaMKII complex drives myocyte-intrinsic and myocyte-extrinsic mechanisms of chemotherapy-induced cardiotoxicity
por: Basak, Madhuri, et al.
Publicado: (2022)

Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor
por: Gulati, Sahil, et al.
Publicado: (2018)

Gαo is a major determinant of cAMP signaling in the pathophysiology of movement disorders
por: Muntean, Brian S., et al.
Publicado: (2021)

RGS Proteins in Heart: Brakes on the Vagus
por: Stewart, Adele, et al.
Publicado: (2012)

MicroRNAs that target RGS5
por: Banaei-Esfahani, Amir, et al.
Publicado: (2015)

Bright flash response recovery of mammalian rods in vivo is rate limited by RGS9
por: Peinado Allina, Gabriel, et al.
Publicado: (2017)

Haploinsufficiency as a disease mechanism in GNB1‐associated neurodevelopmental disorder
por: Schultz‐Rogers, Laura, et al.
Publicado: (2020)

Vascular microarray profiling in two models of hypertension identifies caveolin-1, Rgs2 and Rgs5 as antihypertensive targets
por: Grayson, T Hilton, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_1vpjehsmv1jc01hb5eu5l1s0q3