Ligation Bias in Illumina Next-Generation DNA Libraries: Implications for Sequencing Ancient Genomes

Ancient DNA extracts consist of a mixture of endogenous molecules and contaminant DNA templates, often originating from environmental microbes. These two populations of templates exhibit different chemical characteristics, with the former showing depurination and cytosine deamination by-products, re...

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Detalles Bibliográficos
Autores principales: Seguin-Orlando, Andaine, Schubert, Mikkel, Clary, Joel, Stagegaard, Julia, Alberdi, Maria T., Prado, José Luis, Prieto, Alfredo, Willerslev, Eske, Orlando, Ludovic
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812280/
https://www.ncbi.nlm.nih.gov/pubmed/24205269
http://dx.doi.org/10.1371/journal.pone.0078575

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812280/
https://www.ncbi.nlm.nih.gov/pubmed/24205269
http://dx.doi.org/10.1371/journal.pone.0078575

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