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Ligation Bias in Illumina Next-Generation DNA Libraries: Implications for Sequencing Ancient Genomes
Ancient DNA extracts consist of a mixture of endogenous molecules and contaminant DNA templates, often originating from environmental microbes. These two populations of templates exhibit different chemical characteristics, with the former showing depurination and cytosine deamination by-products, re...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812280/ https://www.ncbi.nlm.nih.gov/pubmed/24205269 http://dx.doi.org/10.1371/journal.pone.0078575 |