Cargando…
Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase promoting complex
The anaphase promoting complex (APC) is the crucial ubiquitin ligase targeting the regulatory machinery of the cell cycle. Emi1, a major modulator of APC activity, is thought to act competitively as a pseudosubstrate. We show that the modulation of APC activity is more subtle: Emi1 inhibits ubiquity...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812805/ https://www.ncbi.nlm.nih.gov/pubmed/23708001 http://dx.doi.org/10.1038/ncb2755 |