NLRP3 is activated in Alzheimer´s disease and contributes to pathology in APP/PS1 mice

Alzheimer´s Disease (AD) is the world’s most common dementing illness. Deposition of amyloid beta peptide (Aβ) drives cerebral neuroinflammation by activating microglia(1,2). Indeed, Aβ activation of the NLRP3 inflammasome in microglia is fundamental for IL-1β maturation and subsequent inflammatory...

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Detalles Bibliográficos
Autores principales: Heneka, Michael T., Kummer, Markus P., Stutz, Andrea, Delekate, Andrea, Schwartz, Stephanie, Saecker, Ana, Griep, Angelika, Axt, Daisy, Remus, Anita, Tzeng, Te-Chen, Gelpi, Ellen, Halle, Annett, Korte, Martin, Latz, Eicke, Golenbock, Douglas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812809/
https://www.ncbi.nlm.nih.gov/pubmed/23254930
http://dx.doi.org/10.1038/nature11729

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812809/
https://www.ncbi.nlm.nih.gov/pubmed/23254930
http://dx.doi.org/10.1038/nature11729

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