Soluble oligomers are sufficient for transmission of a yeast prion but do not confer phenotype

Amyloidogenic proteins aggregate through a self-templating mechanism that likely involves oligomeric or prefibrillar intermediates. For disease-associated amyloidogenic proteins, such intermediates have been suggested to be the primary cause of cellular toxicity. However, isolation and characterizat...

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Detalles Bibliográficos
Autores principales: Dulle, Jennifer E., Bouttenot, Rachel E., Underwood, Lisa A., True, Heather L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812976/
https://www.ncbi.nlm.nih.gov/pubmed/24145167
http://dx.doi.org/10.1083/jcb.201307040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812976/
https://www.ncbi.nlm.nih.gov/pubmed/24145167
http://dx.doi.org/10.1083/jcb.201307040

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