Docking Analysis and Multidimensional Hybrid QSAR Model of 1,4-Benzodiazepine-2,5-Diones as HDM2 Antagonists

The inhibitors of p53-HDM2 interaction are attractive molecules for the treatment of wild-type p53 tumors. In order to search more potent HDM2 inhibitors, docking operation with CDOCKER protocol in Discovery Studio 2.1 (DS2.1) and multidimensional hybrid quantitative structure-activity relationship...

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Detalles Bibliográficos
Autores principales: Dai, Yujie, Chen, Nan, Wang, Qiang, Zheng, Heng, Zhang, Xiuli, Jia, Shiru, Dong, Lilong, Feng, Dacheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813138/
https://www.ncbi.nlm.nih.gov/pubmed/24250508

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813138/
https://www.ncbi.nlm.nih.gov/pubmed/24250508

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