Polymorphic Sites at the Immunoregulatory CTLA-4 Gene Are Associated with Chronic Chagas Disease and Its Clinical Manifestations

BACKGROUND: Chagas disease affects approximately 10 million people mainly in Latin America. The immune regulation by the host seems to be an essential factor for disease evolution, and immune system inhibitory molecules such as CTLA-4 and PD-1 favor the maintenance of peripheral tolerance. Consideri...

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Detalles Bibliográficos
Autores principales: Dias, Fabrício C., Medina, Tiago da S., Mendes-Junior, Celso T., Dantas, Roberto O., Pissetti, Cristina W., Rodrigues Junior, Virmondes, Dellalibera-Joviliano, Renata, Marin-Neto, José A., Gutierrez, Fredy R. S., Moreau, Philippe, Silva, João S., Donadi, Eduardo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813449/
https://www.ncbi.nlm.nih.gov/pubmed/24205212
http://dx.doi.org/10.1371/journal.pone.0078367

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813449/
https://www.ncbi.nlm.nih.gov/pubmed/24205212
http://dx.doi.org/10.1371/journal.pone.0078367

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