Quantitative Phosphoproteome Analysis Unveils LAT as a Modulator of CD3ζ and ZAP-70 Tyrosine Phosphorylation

Signaling through the T cell receptor (TCR) initiates adaptive immunity and its perturbation may results in autoimmunity. The plasma membrane scaffolding protein LAT acts as a central organizer of the TCR signaling machinery to activate many functional pathways. LAT-deficient mice develop an autoimm...

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Detalles Bibliográficos
Autores principales: Salek, Mogjiborahman, McGowan, Simon, Trudgian, David C., Dushek, Omer, de Wet, Ben, Efstathiou, Georgios, Acuto, Oreste
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813684/
https://www.ncbi.nlm.nih.gov/pubmed/24204825
http://dx.doi.org/10.1371/journal.pone.0077423

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813684/
https://www.ncbi.nlm.nih.gov/pubmed/24204825
http://dx.doi.org/10.1371/journal.pone.0077423

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