Synthetic Lethal Targeting of Superoxide Dismutase 1 Selectively Kills RAD54B-Deficient Colorectal Cancer Cells

Synthetic lethality is a rational approach to identify candidate drug targets for selective killing of cancer cells harboring somatic mutations that cause chromosome instability (CIN). To identify a set of the most highly connected synthetic lethal partner genes in yeast for subsequent testing in ma...

Descripción completa

Detalles Bibliográficos
Autores principales: Sajesh, Babu V., Bailey, Melanie, Lichtensztejn, Zelda, Hieter, Philip, McManus, Kirk J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2013
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813862/
https://www.ncbi.nlm.nih.gov/pubmed/24002644
http://dx.doi.org/10.1534/genetics.113.156836

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813862/
https://www.ncbi.nlm.nih.gov/pubmed/24002644
http://dx.doi.org/10.1534/genetics.113.156836

Ejemplares similares