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Requirement for phosphorylation of P53 at Ser312 in suppression of chemical carcinogenesis
The p53 tumour suppressor is activated in response to a wide variety of genotoxic stresses, frequently via post-translational modification. Using a knock in mouse model with a Ser312 to Ala mutation, we show here that phosphorylation of p53 on Ser312 helps to prevent tumour induction by the alkylati...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813944/ https://www.ncbi.nlm.nih.gov/pubmed/24173284 http://dx.doi.org/10.1038/srep03105 |