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Endosomal acidification by Na(+)/H(+) exchanger NHE5 regulates TrkA cell-surface targeting and NGF-induced PI3K signaling
To facilitate polarized vesicular trafficking and signal transduction, neuronal endosomes have evolved sophisticated mechanisms for pH homeostasis. NHE5 is a member of the Na(+)/H(+) exchanger family and is abundantly expressed in neurons and associates with recycling endosomes. Here we show that NH...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Cell Biology
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814139/ https://www.ncbi.nlm.nih.gov/pubmed/24006492 http://dx.doi.org/10.1091/mbc.E12-06-0445 |