Sterol-induced dislocation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from membranes of permeabilized cells

The polytopic endoplasmic reticulum (ER)–localized enzyme 3-hydroxy-3-methylglutaryl CoA reductase catalyzes a rate-limiting step in the synthesis of cholesterol and nonsterol isoprenoids. Excess sterols cause the reductase to bind to ER membrane proteins called Insig-1 and Insig-2, which are carrie...

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Detalles Bibliográficos
Autores principales: Elsabrouty, Rania, Jo, Youngah, Dinh, Tammy T., DeBose-Boyd, Russell A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814148/
https://www.ncbi.nlm.nih.gov/pubmed/24025715
http://dx.doi.org/10.1091/mbc.E13-03-0157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814148/
https://www.ncbi.nlm.nih.gov/pubmed/24025715
http://dx.doi.org/10.1091/mbc.E13-03-0157

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