ALS-Associated FUS Mutations Result in Compromised FUS Alternative Splicing and Autoregulation

The gene encoding a DNA/RNA binding protein FUS/TLS is frequently mutated in amyotrophic lateral sclerosis (ALS). Mutations commonly affect its carboxy-terminal nuclear localization signal, resulting in varying deficiencies of FUS nuclear localization and abnormal cytoplasmic accumulation. Increasin...

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Detalles Bibliográficos
Autores principales: Zhou, Yueqin, Liu, Songyan, Liu, Guodong, Öztürk, Arzu, Hicks, Geoffrey G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814325/
https://www.ncbi.nlm.nih.gov/pubmed/24204307
http://dx.doi.org/10.1371/journal.pgen.1003895

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814325/
https://www.ncbi.nlm.nih.gov/pubmed/24204307
http://dx.doi.org/10.1371/journal.pgen.1003895

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