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ALS-Associated FUS Mutations Result in Compromised FUS Alternative Splicing and Autoregulation

The gene encoding a DNA/RNA binding protein FUS/TLS is frequently mutated in amyotrophic lateral sclerosis (ALS). Mutations commonly affect its carboxy-terminal nuclear localization signal, resulting in varying deficiencies of FUS nuclear localization and abnormal cytoplasmic accumulation. Increasin...

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Detalles Bibliográficos
Autores principales:	Zhou, Yueqin, Liu, Songyan, Liu, Guodong, Öztürk, Arzu, Hicks, Geoffrey G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814325/ https://www.ncbi.nlm.nih.gov/pubmed/24204307 http://dx.doi.org/10.1371/journal.pgen.1003895

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