Defective Viral Genomes Arising In Vivo Provide Critical Danger Signals for the Triggering of Lung Antiviral Immunity

The innate immune response to viruses is initiated when specialized cellular sensors recognize viral danger signals. Here we show that truncated forms of viral genomes that accumulate in infected cells potently trigger the sustained activation of the transcription factors IRF3 and NF-κB and the prod...

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Detalles Bibliográficos
Autores principales: Tapia, Karla, Kim, Won-keun, Sun, Yan, Mercado-López, Xiomara, Dunay, Emily, Wise, Megan, Adu, Michael, López, Carolina B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814336/
https://www.ncbi.nlm.nih.gov/pubmed/24204261
http://dx.doi.org/10.1371/journal.ppat.1003703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814336/
https://www.ncbi.nlm.nih.gov/pubmed/24204261
http://dx.doi.org/10.1371/journal.ppat.1003703

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