Replication fork collapse is a major cause of the high mutation frequency at three-base lesion clusters

Unresolved repair of clustered DNA lesions can lead to the formation of deleterious double strand breaks (DSB) or to mutation induction. Here, we investigated the outcome of clusters composed of base lesions for which base excision repair enzymes have different kinetics of excision/incision. We desi...

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Detalles Bibliográficos
Autores principales: Sedletska, Yuliya, Radicella, J. Pablo, Sage, Evelyne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814351/
https://www.ncbi.nlm.nih.gov/pubmed/23945941
http://dx.doi.org/10.1093/nar/gkt731

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814351/
https://www.ncbi.nlm.nih.gov/pubmed/23945941
http://dx.doi.org/10.1093/nar/gkt731

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