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Efficient generation of large-scale genome-modified mice using gRNA and CAS9 endonuclease
The generation of genome-modified animals is a powerful approach to analyze gene functions. The CAS9/guide RNA (gRNA) system is expected to become widely used for the efficient generation of genome-modified animals, but detailed studies on optimum conditions and availability are limited. In the pres...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814358/ https://www.ncbi.nlm.nih.gov/pubmed/23997119 http://dx.doi.org/10.1093/nar/gkt772 |