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Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors
We previously identified 28 cofactors through which a RAS oncoprotein directs transcriptional silencing of Fas and other tumor suppressor genes (TSGs). Here we performed RNAi-based epistasis experiments and found that RAS-directed silencing occurs through a highly ordered pathway that is initiated b...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814642/ https://www.ncbi.nlm.nih.gov/pubmed/24105743 http://dx.doi.org/10.1101/gad.227413.113 |