Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors

We previously identified 28 cofactors through which a RAS oncoprotein directs transcriptional silencing of Fas and other tumor suppressor genes (TSGs). Here we performed RNAi-based epistasis experiments and found that RAS-directed silencing occurs through a highly ordered pathway that is initiated b...

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Detalles Bibliográficos
Autores principales: Wajapeyee, Narendra, Malonia, Sunil K., Palakurthy, Rajendra K., Green, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2013
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814642/
https://www.ncbi.nlm.nih.gov/pubmed/24105743
http://dx.doi.org/10.1101/gad.227413.113

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