A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage

Senataxin (SETX) is an RNA/DNA helicase implicated in transcription termination and the DNA damage response and is mutated in two distinct neurological disorders: AOA2 (ataxia oculomotor apraxia 2) and ALS4 (amyotrophic lateral sclerosis 4). Here we provide evidence that Rrp45, a subunit of the exos...

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Detalles Bibliográficos
Autores principales: Richard, Patricia, Feng, Shuang, Manley, James L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2013
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814643/
https://www.ncbi.nlm.nih.gov/pubmed/24105744
http://dx.doi.org/10.1101/gad.224923.113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814643/
https://www.ncbi.nlm.nih.gov/pubmed/24105744
http://dx.doi.org/10.1101/gad.224923.113

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