Bubble-seq analysis of the human genome reveals distinct chromatin-mediated mechanisms for regulating early- and late-firing origins

We have devised a method for isolating virtually pure and comprehensive libraries of restriction fragments that contained replication initiation sites (bubbles) in vivo. We have now sequenced and mapped the bubble-containing fragments from GM06990, a near-normal EBV-transformed lymphoblastoid cell l...

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Detalles Bibliográficos
Autores principales: Mesner, Larry D., Valsakumar, Veena, Cieślik, Marcin, Pickin, Rebecca, Hamlin, Joyce L., Bekiranov, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814878/
https://www.ncbi.nlm.nih.gov/pubmed/23861383
http://dx.doi.org/10.1101/gr.155218.113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814878/
https://www.ncbi.nlm.nih.gov/pubmed/23861383
http://dx.doi.org/10.1101/gr.155218.113

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