Bozepinib, a novel small antitumor agent, induces PKR-mediated apoptosis and synergizes with IFNα triggering apoptosis, autophagy and senescence

Bozepinib [(RS)-2,6-dichloro-9-[1-(p-nitrobenzenesulfonyl)-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]-9H-purine] is a potent antitumor compound that is able to induce apoptosis in breast cancer cells. In the present study, we show that bozepinib also has antitumor activity in colon cancer cells, show...

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Detalles Bibliográficos
Autores principales: Marchal, Juan Antonio, Carrasco, Esther, Ramirez, Alberto, Jiménez, Gema, Olmedo, Carmen, Peran, Macarena, Agil, Ahmad, Conejo-García, Ana, Cruz-López, Olga, Campos, Joaquin María, García, María Ángel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815003/
https://www.ncbi.nlm.nih.gov/pubmed/24194639
http://dx.doi.org/10.2147/DDDT.S51354

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815003/
https://www.ncbi.nlm.nih.gov/pubmed/24194639
http://dx.doi.org/10.2147/DDDT.S51354

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