Characterization and Prediction of Haploinsufficiency Using Systems-Level Gene Properties in Yeast

Variation in gene copy number can significantly affect organism fitness. When one allele is missing in a diploid, the phenotype can be compromised because of haploinsufficiency. In this work, we identified associations between Saccharomyces cerevisiae gene properties and genome-scale haploinsufficie...

Descripción completa

Detalles Bibliográficos
Autores principales: Norris, Matthew, Lovell, Simon, Delneri, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2013
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815059/
https://www.ncbi.nlm.nih.gov/pubmed/24048642
http://dx.doi.org/10.1534/g3.113.008144

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815059/
https://www.ncbi.nlm.nih.gov/pubmed/24048642
http://dx.doi.org/10.1534/g3.113.008144

Ejemplares similares