Zygotic Porcn Paternal Allele Deletion in Mice to Model Human Focal Dermal Hypoplasia

In mouse and humans, the X-chromosomal Porcupine homolog (Porcn) gene is required for the acylation and secretion of all 19 Wnt ligands, thus representing a bottleneck in the secretion of Wnt ligands. In humans, mutations in PORCN cause the X-linked dominant syndrome Focal Dermal Hypoplasia (FDH, OM...

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Detalles Bibliográficos
Autores principales: Biechele, Steffen, Adissu, Hibret A., Cox, Brian J., Rossant, Janet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815152/
https://www.ncbi.nlm.nih.gov/pubmed/24223895
http://dx.doi.org/10.1371/journal.pone.0079139

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815152/
https://www.ncbi.nlm.nih.gov/pubmed/24223895
http://dx.doi.org/10.1371/journal.pone.0079139

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