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Probing the heterologous metabolism supporting 6‐deoxyerythronolide B biosynthesis in Escherichia coli

Heterologous biosynthesis offers a new way to capture the medicinal properties presented by complex natural products. In this study, production of 6‐deoxyerythronolide B (6dEB), the polyketide precursor to the antibiotic erythromycin, was used to probe the heterologous pathways needed for Escherichi...

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Detalles Bibliográficos
Autores principales: Zhang, Haoran, Wang, Yong, Boghigian, Brett, Pfeifer, Blaine A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815759/
https://www.ncbi.nlm.nih.gov/pubmed/21261933
http://dx.doi.org/10.1111/j.1751-7915.2009.00099.x