Synergistic apoptotic response between valproic acid and fludarabine in chronic lymphocytic leukaemia (CLL) cells involves the lysosomal protease cathepsin B

Fludarabine, a nucleoside analogue, is commonly used in combination with other agents for the treatment of chronic lymphocytic leukaemia (CLL). In previous studies, valproic acid (VPA), an inhibitor of histone deacetylases, combined with fludarabine to synergistically increase apoptotic cell death i...

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Detalles Bibliográficos
Autores principales: Yoon, J-Y, Szwajcer, D, Ishdorj, G, Benjaminson, P, Xiao, W, Kumar, R, Johnston, J B, Gibson, S B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816211/
https://www.ncbi.nlm.nih.gov/pubmed/24141622
http://dx.doi.org/10.1038/bcj.2013.50

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816211/
https://www.ncbi.nlm.nih.gov/pubmed/24141622
http://dx.doi.org/10.1038/bcj.2013.50

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